Evidence method
Peptide research reference methodology
Every monograph is reviewed as four separate questions: what the reference substance is, what the source studied, what the evidence cannot establish, and what U.S. authorities currently say.
Source hierarchy
The source controls the claim.
A source is cited only for the fact it can support. A database record, a cell experiment, an animal model, and a human trial are not interchangeable evidence.
FDA labels, DailyMed, FDA substance records, and current FDA reviews control approval, identity, and U.S. regulatory context.
ClinicalTrials.gov controls registered study status. Registration does not establish a result or authorize another material.
PubMed-indexed papers establish only the substance, model, method, and findings actually reported by the authors.
PubChem supports reference identifiers, formulas, and molecular mass. It does not verify a supplier, package, or lot.
Evidence labels
Stage is visible on every record.
The label describes the strongest source represented in the monograph. It is not a quality grade or a recommendation.
An approved named drug product exists. Approval does not transfer to another source or material.
A human investigational program is registered or published; the library makes no approval claim.
Human research exists, but its scope and limitations remain explicit.
The represented work is cellular, analytical, or animal research.
The supplied name does not resolve to one unambiguous molecular identity.
A combination is indexed by its parts; no mixture-level conclusion is assigned.
Correction rule
Uncertainty stays visible.
Conflicting names, salt forms, counterions, sequences, and mixture definitions remain unresolved until exact records close the gap. Monographs are revised when a controlling source changes.